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Significant reductions in body weight and improvements in glycaemic control have been demonstrated in early-phase clinical trials, most notably the Phase 2 trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)
doi: 10.1016/j.cell.2016.09.014 43 FinanBYangBOttawayNStemmerKMullerTDYiCXet al
Growth doesn't always come from changing companies
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Smoking cessation benefits GERD through multiple mechanisms
The careful conclusion is that 4 mg may be a transition pointnot a proven biological threshold
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