5-Amino-1MQ inhibits the NNMT enzyme to theoretically raise NAD+ levels and improve insulin sensitivity, but evidence is limited to preclinical animal studies only
And it's something that we're definitely going to be exploring more on this podcast, both with expert guests and in solo episodes going forward
Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]
Zhao X, Si L, Bian J, Pan C, Guo W, Qin P, et al
Several groups have studied dermal papilla cell cultures exposed to copper-bound tripeptide and have observed differentiation-marker shifts
GHK-Cu is particularly relevant for this population because of its documented ability to remodel UV-damaged collagen and activate the skin's antioxidant defenses against ongoing solar damage