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The C-terminal and N-terminal ends of ZIP are located either on the cell surface or within the lumen of the organelle

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Indeed, the primary transcripts affected in fetal liver under a maternal nutrient restriction scenario are those associated with AA metabolism and epigenetic modification, such as methyltransferases ( Evaluating the impacts of maternal RPM supplementation during the periconceptional period (115 d) on postnatal beef calves, Silva et al

Hepatology 66 , 449465 (2017)

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NAC may be useful when: Cysteine availability may be limiting The goal is to support internal glutathione synthesis Direct glutathione is poorly tolerated A clinician has identified a relevant medical or nutritional reason NAC does not guarantee that glutathione production will increase adequately