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The cjc ipa mix keeps effectiveness better than constant GH use due to its pulsatile pattern, but periodic breaks help preserve receptor response and keep best responses

Three authors (MM, AN, and JV) independently screened titles and abstracts following de-duplication

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227 SUSTAIN-6 (3,297 participants, median two years) found semaglutide provided an even greater relative risk reduction compared with placebo (HR 0.74

Thus, we determined ER-stress response genes Xbp1 and the ER chaperone heat shock 70 kDa protein 5 (HSPA5, previously known as immunoglobulin heavy chain binding protein [BIP]), inflammation-responsive genes IL6 and IL1, and hypoxia-responsive genes hypoxia-inducible transcription factor 1 (HIF1) and GAPDH