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Direct comparison: SURMOUNT-5 The SURMOUNT-5 trial (2025) provided the first large randomized head-to-head comparison of tirzepatide versus semaglutide in adults with obesity without diabetes

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95 : 212221 Horsten M, Wamala SP, Vingerhoets A, Orth-Gomer K

3), in addition to switching-off fatty acid release from triglycerides (TG) in fat and muscle tissues

10.2337/dc15-1707 49

Given the size of the California oversample needed to assure statistical reliability both nationally and within California, firm weights were calibrated to California-specific targets from the SUSB