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Phase 2 data reported nausea (~42%), vomiting (~20%), and diarrhoea (~18%) in the highest dose cohort, consistent with the GLP-1 class

Eligibility criteria typically include BMI thresholds (most commonly 27+ with comorbidities or 30+ without), age (usually 18+), and absence of contraindications (pregnancy, certain cancer histories, severe GI disease)

Thus clinical data on GLP-1 agonists in brain-related conditions remain limited

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