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10.1016/0009-8981(85)90020-8 Sugimoto T, Muro H, Woo M, Nishida N, Murakami K: Valproate metabolites in high-dose valproate plus phenytoin therapy

Together, these advances highlight a shift toward a systems-level framework in PD biomarker discovery, where microbial dysbiosis, metabolite fluctuations, immune signatures, and -synuclein seeding activity are viewed as interconnected outputs of the gutimmunebrain network rather than isolated signals

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Instead, they are often discussed as part of a broader care plan