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2021 NEJM) The semaglutide peptide sequence is public
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A modest increase in heart rate was also observed, a signal seen with other incretin-based weight-loss agents
Some research has raised concerns about potential negative effects on insulin sensitivity and liver fat with long-term use
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Critics also highlight conflicts of interest : when PBMs own pharmacies, questions arise whether they steer business to their own outlets (or impose unfavorable terms on independent pharmacies)
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