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DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation
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It does this through the activity of the glutathione-dependent enzyme dehydroascorbate reductase
Injectable hydrogel formulations provide conformal coverage of irregular wound geometries, whereas porous cryogels and nanofiber composites ensure mechanical resilience and sustained oxygenation in deep or chronic lesions
Similarly, men who are exposed to chemicals, pesticides, or solvents at work have been found to experience greater oxidative damage in their sperm, leading to reduced fertility
Mishra M, Zhong Q, Kowluru RA (2014) Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic retinopathy
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