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During mitochondrial metabolism, ROS are generated as toxic byproducts that are neutralized by GPx3

Reduced Antioxidant Protection Glutathione is known for its powerful antioxidant properties, which help protect the body from oxidative stress and free radical damage

However, like -cells, the likely redundancy of diuretic-sensitive mechanisms involved in the regulation of hepatocyte [Cl ] i makes it challenging to study the role of loop diuretics on hepatic glucose metabolism

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Mitochondria, which are structures within the cells of the RPE that act as energy powerhouses, are particularly susceptible to ROS-induced damage [17]

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