One possibility for such a protein is ProX, the substrate binding periplasmic protein of the ProVWX glycine betaine ABC transporter, which in Escherichia coli is known to bind l-proline 24
From the phase 3 trials at the 9 mg and 12 mg doses: Nausea: 38.1% (9 mg) to 43.2% (12 mg) versus 10.7% with placebo Diarrhea: 34.7% (9 mg) to 33.1% (12 mg) versus 13.4% with placebo Constipation: 21.8% (9 mg) to 25.0% (12 mg) versus 8.7% with placebo Vomiting: 20.4% (9 mg) to 20.9% (12 mg) Compare those numbers to Mounjaro and the difference is clear
For those with mild reflux or IBS, the medication can still be used but requires careful management
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Notably, oxidative phosphorylation efficiency at complexes I and IIspecifically when glucose was the fuel sourceemerged as a stronger predictor of GWS severity than markers of peripheral inflammation