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Expert Opin Investigational Drugs
Tirzepatide activates both GLP-1 and GIP receptors, resulting in more potent weight loss (2022% in trials)
For instance, activation of Sirt1 reduced toxin-induced neuronal death, whereas inhibition of Sirt2 ameliorated S-mediated cell death in PD models (Figure 3) ( FIGURE 3 Glial cytoplasmic inclusion of S is the pathological hallmark of multiple system atrophy
GLP-1 receptor agonists mimic this natural hormone, offering improved glycemic control for people with type 2 diabetes
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