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It is well known that HFD-induced obesity promotes low-grade hypothalamic inflammation, causing deregulation of central mechanisms that control energy homeostasis 59 , and both physical exercise and some pharmacotherapies have been shown to improve systemic metabolism by attenuating hypothalamic inflammation 60,61
4 A relevant interaction is also observed between GLP-1R agonists and the gut microbiota, although the specific effects of GLP-1 receptor signaling on this axis remain only partially elucidated
Phosphate buffered saline (PBS) (pH 7.4, 10) was obtained from Vivantis (Malaysia)
PT-141 is a synthetic peptide that activates melanocortin receptors in the brain, mainly MC3 and MC4, which help regulate arousal and desire
Sources: CLC016638.A This content is not intended to be a substitute for professional medical advice, diagnosis or treatment
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