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This is a follow-up study on the earlier studies that expanded the number of loci

Histone acetylation and methylation have similarly been implicated in the activation and repression of secondary metabolic pathways (Hu et al., 2019), while enhancer-associated elements contribute additional layers of transcriptional regulation (Oka et al., 2017)

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Once inside the cell, the -glutamyl-amino acid can be metabolized to release the amino acid and 5-oxoproline, which can then be converted into glutamate to be used in the synthesis of GSH