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In the DIO mouse studies, no adverse effects on liver enzymes, kidney function markers, or hematologic parameters were reported during the treatment period

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Research involving ALS patients and model mice has revealed EC degeneration, characterized by cellular damage, swelling, and cytoplasmic vacuolization, along with diminished levels of TJs such as ZO-1, claudin-V, and occluding [241]

Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells