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They got weekly injections of either Ozempic or placebo for 68 weeks, tracking two main outcomes: body weight and pain (WOMAC pain score, a well-established scoring system for knee osteoarthritis)

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Escalation reduces side effects The comparison between the 4mg escalated and 4mg non-escalated cohorts provides critical insight into dosing strategy

Tirzepatide, a peptide-based GLP-1/GIP dual agonist, produces a larger mean weight loss in trials than many older drugs

Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the receptor every GLP-1 compound binds), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (tied to glucose handling and GLP-1 secretion) describe the metabolic terrain a clinician prescribes into