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CRH released from mast cell acts in an autocrine as well as paracrine manner to activate mast cells and glial cells in the CNS in stress and neuroinflammatory conditions (Karagkouni et al., 2013

This effect may not be surprising, as semaglutide is already FDA-approved for diabetes management under Novo Nordisks other brand name, Ozempic

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A real-world data analysis of tirzepatide in the FDA adverse event reporting system (FAERS) database

The primary mechanism involves slowing gastric emptying, which increases satiety and reduces food intake

Light/dark box test The light/dark box test reliably predicts anxiolytic and anxiogenic-like effects in rodents and offers quick, easy performance without prior animal training or food/water deprivation