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While cortisone is highly effective at quickly reducing inflammation and pain, it can cause issues with long-term use, such as tissue atrophy, weakened tendons, and blood sugar elevation

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Exposure of healthy organs to medication is unnecessary and most often will lead to side or toxic effects which are especially an issue for medication with a narrow therapeutic index

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Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics