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Pre-clinical research conducted primarily in animal models informs the hypotheses for its use, but no large randomized controlled trials in humans have confirmed efficacy for any outcome - including gut-lining support, tissue-related processes, or any other claimed mechanism

While this effect is minor in a sealed vial over the short term, refrigeration helps keep the preservative where it belongs: in the solution

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Vaginal dryness causes discomfort and pain in your vagina, especially during sex

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