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Tirzepatide is a medication that improves insulin sensitivity, which can be evaluated indirectly through fasting biomarkers such as glucose and insulin and the homeostasis model assessment of insulin resistance (HOMA2-IR)

Qin Z, Du T, Zheng Y, Luo P, Zhang J, Xie M, et al

Enhanced healing of ulcers in patients with diabetes by treatment with glycyl-l-histidyl-l-lysine copper

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Because they work by making existing insulin more effective rather than increasing insulin levels directly, hypoglycemia is less of a concern than with sulfonylureas