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when prescribed off-label, 5%10% potential weight loss Daily GLP-1 Injections (Flexible Dosing): Saxenda (liraglutide)*: FDA-approved specifically for weight management in adults and adolescents with obesity to control appetite

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Advertisement Together, these findings suggest that semaglutide provides both renal and systemic benefits by addressing metabolic and inflammatory pathways underlying CKD progression

Liraglutide vs Retatrutide: Cost and Access Head-to-Head At a glance Liraglutide / FDA-approved since 2014 (Saxenda for obesity, Victoza for type 2 diabetes) Retatrutide / Investigational, Phase 3 trials ongoing (estimated completion 2025-2026) SCALE trial weight loss / 8.0% mean body-weight reduction at 56 weeks with liraglutide 3.0 mg Phase 2 trial weight loss / 24.2% mean body-weight reduction at 48 weeks with retatrutide 12 mg Liraglutide generic retail cost / approximately $25-$100 per month for generic versions Saxenda branded cost / approximately $1,300-$1,500 per month without insurance Retatrutide cost / not commercially available