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B12 is especially beneficial for individuals who have difficulty absorbing B12 from food or oral supplements, which can occur due to certain digestive disorders, age-related changes, or specific medical conditions
However, high doses ( 0.5 mg/kg/d) may activate the SREBP-1c pathway, increase liver fat synthesis, and lead to hypertriglyceridemia and fatty liver
"People living with obesity need treatment options that meet them where they are and for many, a once-daily pill that can be taken with no food or water restrictions can offer them greater flexibility in how they approach their treatment," said Deborah Horn , DO, Director of the Center for Obesity Medicine at McGovern Medical School at UTHealth Houston
Others prefer evening injections so they can sleep through the initial side effects
GLP-1 receptor agonists are well established to slow gastric emptying the rate at which food moves from the stomach into the small intestine
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