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6.1 Osteocalcin as an endocrine regulator of metabolism Osteocalcin is the most extensively studied endocrine peptide derived from bone

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This delayed induction of Cyclin D1 and CDK4 partners controlling the progression in late G1 phase led to alteration in E2F1 accumulation that allows the coordination of gene transcription necessary for DNA replication

This means B12 deficiency is real and underdiagnosed, but it is not universal and not everyone experiencing fatigue has a B12 problem