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doi:10.1073/pnas.1408886111
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Berberine is a naturally occurring alkaloid compound extracted from various plants, including Berberis species (barberry), goldenseal, and Chinese goldthread
G., Lopez, E., Krishnan, K., & Bittner, E
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The flip side is that the long half-life also creates relatively stable medication levels between doses, which can actually reduce side effect intensity compared to medications with more dramatic peaks and troughs
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