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Silverii 2021
Improves Skin and Reduces Hypertrophic Scars: By regulating inflammation and promoting balanced collagen production, it may increase the rate of wound closure and reduce the development of hypertrophic scars
Given that inhibition of IGF-IR may paradoxically lead to upregulation of IGF1/2 expression, and IGF1/2 have IGF-IR/InsR-independent functions, it warrants to investigate whether co-targeting IGF and IGF-IR/InsR-A may achieve objective responses
USA 110 , 88828887 (2013)
National Academies Press
While exposure to the synthetic GHSR1a agonist MK-0677 results in an increase in internalization, this increase does not reach significance when compared to control, whereas it does reach significance compared to SP-analog (Schellekens et al., 2013)
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