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doi: 10.1016/j.canlet.2018.07.017 65 CasariGRomaldiBScirAMinnelliCMarzioniDFerrettiGet al

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Animal models have demonstrated that GLP-1 RAs reduce drug-seeking behavior and attenuate conditioned place preference for substances such as alcohol, nicotine, and cocaine (32)

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( GLP-1 RAs recently appearing on the market, in particular liraglutide, semaglutide and tirzepatide (a GIP/GLP-1 RA dual agonist) seek to overcome the problem of the short plasma half-life of native GLP-1 through (i) changing the amino acid sequence of the peptide so that it is no longer broken down by DPP-4, and/or (ii) attaching a long acyl chain to the peptide, thus allowing it to bind to albumin, and avoid rapid elimination via the kidney