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After the enrolment period, patients were randomly assigned to one of two groups for 24-weeks: insulin therapy with or without saxagliptin (SAXA group and CONT group)

whereas, the addition of LiCl resulted in the further upregulation of Wnt3a, LRP5, and -catenin mRNA and protein levels

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Additionally, a positive feedback loop between oxidative stress and TRIM28 activity further amplifies ferroptosis

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At the same time, AOD-9604 suppresses the enzymes that facilitate fat storage, preventing new fat cells from forming