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Sindhuja, A., Vimalavathini, S
J Clin Invest 117:21552163 Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
If you already deal with constipation on your GLP-1 , early dosing can make it worse for a few days
But they may also exacerbate issues (like constipation or periodic diarrhoea and nausea) due to the very same mechanisms
S2CID 6994133
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