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Publisher International Journal of Molecular Sciences Accessed Jun 27, 2026 Study type Systematic Review Limitations: Biological plausibility is not the same as a verified treatment claim for people
Certain health conditions If you have a stomach or small intestine condition such as celiac disease or Crohn's disease, you may not be able to absorb enough vitamin B12 from food
Our physicians expect it
Summary: Excessive vitamin B12 intake rarely causes toxicity, but very high levels from supplements or injections may be associated with skin reactions such as acne-like eruptions, though serious adverse effects remain exceptionally uncommon
Altitude and air pressure At higher altitudes, lower air pressure can cause the rubber stopper to resist needle insertion differently, and drawing water into the syringe may feel slightly different
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