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Prevalence of carnitine deficiency and decreased carnitine levels in patients on hemodialysis

An early study showed that DPP-IV lability of GLP-1 could be reduced by introducing alternative amino acids at position 8 (36)

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PT-141 is also metabolised by peptidases, but its cyclic structure makes it more resistant to enzymatic degradation than linear peptides, which is why subcutaneous bioavailability exceeds 80%