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an effect that has led to FDA approval of several GLP-1 therapies specifically for obesity
Tirzepatide has also shown some promising results with up to 8% absolute reduction in liver fat content in a RCT
Another study using NR supplementation showed that doses up to 1000 mg per day for 10 weeks were well tolerated in patients affected by mild cognitive impairments (MCI) 246
No human pregnancy studies definitively link GLP-1 agonists to birth defects, but animal studies in rodents have shown some metabolic effects at high doses
SGLT2i models were most sensitive to the effect of SGLT2is on all-cause mortality and ESKD, as well as the underlying incidence of ESKD in the model and annual cost of ESKD
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