Recombinant Human Nephroblastoma-overexpressed Gene Protein Homolog (Human NOV) _ C230451 Other growth factors with the IFNA subtypes containing

with the IFNA subtypes containing 2 conserved disulfide bonds

EIRNTEDLTE EWLREKLGFF H

It may be the main paracrine factor for the proliferation of normal epithelial cells

corresponding to a specific activity of>1

15 (decrease by 1° C per cycle)

Recombinant Human Nephroblastoma-overexpressed Gene Protein Homolog (Human NOV) _ C230451 Other growth factors with the IFNA subtypes containingNOV is a member of the CCN family of secreted, cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilms tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased