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The activation of endothelial cells in association with the fibroblasts may lead to a strengthened skin barrier and increased skin elasticity, as well as potential acceleration in tissue repair
Normal dermal fibroblasts were seeded into a 96-well cell culture plate and have been grown to confluence in high glucose media, supplemented with 10% fetal calf serum for around 3 days
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This hypothesized VEGF/VEGFR interaction may activate a complex intracellular signaling cascade, which may involve multiple proteins such as phospholipase C, protein kinase C, and the mitogen-activated protein kinases
AHK-Cu, or Alanine-Histidine-Lysine-Copper, is a naturally occurring tripeptide complexed with copper that has been investigated for its role in activating copper-dependent enzymatic processes and modulating extracellular matrix proteins involved in tissue structure and repair
Therefore AHK-Cu may have potential action on blood vessel growth as well, which may further enhance the function of fibroblasts
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