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131 In addition, gene polymorphisms can alter astrocyte responses to pathologies and contribute to disorder progression, as for example with APOE polymorphisms in AD or traumatic injuries, 132,133,134,135 or with CD38 polymorphisms in PD

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Standard community protocols run tirzepatide alone for the first 8 weeks (2.5 5 mg/week) to confirm GI tolerance, then add cagrilintide at 0.25 mg/week starting Week 9

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