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The clinical evidence base for these two compounds differs substantially in maturity, scope, and regulatory recognition
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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility A 2-year carcinogenicity study was conducted with tirzepatide in male and female rats at doses of 0.15, 0.50, and 1.5 mg/kg (0.1-, 0.4-, and 1-fold the MRHD of 15 mg once weekly based on AUC) administered by subcutaneous injection twice weekly
Efectos gastrointestinales: Los efectos secundarios ms comunes son gastrointestinales, incluyendo nuseas (15-30% de pacientes), diarrea, vmitos, estreimiento y dolor abdominal
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