doi: 10.3390/antiox12071444 122 JiangL.KiselovaN.RosnJ.IlagL
A recent randomized controlled trial treating adolescents aged 1018 years with obesity for 6 months with GLP-1 RA investigated the consequence on the endogenous levels of GLP-1, glucagon and insulin
Based on the findings, GLP-1RAs are evolving into multisystem therapies with expanding roles beyond diabetes, including cardiovascular, renal, and hepatic benefits, as well as potential neurocognitive benefits
Additionally, a 10-week study in overweight or obese post-menopausal women with prediabetes found that 250 mg NMN per day partially increased muscle insulin signaling and sensitivity, but no change in mitochondrial oxidative capacity was found 324
One proposed mechanism is that low B12 may influence adipogenic gene expression through hypomethylation [27], though further mechanistic studies are needed to confirm this pathway
Supplement allocation was implemented using 6-digit randomization codes, with the list generated by an unblinded individual not involved in conducting the study