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While pooled data from the SURPASS clinical trial programme indicate that tirzepatide does not increase the risk of major cardiovascular events [61], definitive conclusions regarding its cardiovascular profile should await the results of SURPASS-CVOT, with its completion anticipated in late 2024 [60]

doi: 10.1371/journal.pone.0186802

Why it matters: Dehydration worsens constipation, fatigue, and can be dangerous if you're also experiencing vomiting or diarrhea

Other factors such as hypertension, high cholesterol, and obstructive sleep apnea also elevate individual risk

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