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This work was partly supported by the MEC project BIO2005-08898-C02-1, BioCARM project BIO2005/01-6468 and Sneca project 02928/PI/05

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In phase 2 TOPAZ (NCT03921528) and phase 3 SAPPHIRE (NCT05156320) trials, apitegromab treatment improved motor function in patients with spinal muscular atrophy (SMA) 9,16

Strong data governance helps create the foundation for trustworthy AI by improving consistency, context, access controls, and confidence in AI-generated outputs

[26] [27] They also act on appetite centres in the brain, particularly the hypothalamus, to reduce hunger signals and increase satiety