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One of the most common hurdles is gastrointestinal side effects, which are dose-dependent and include nausea, vomiting, diarrhea, and constipation
Wegovy, Zepbound, and Saxenda removed from formulary
Diabetes 58, 15261531
Wang L, Volkow ND, Kaelber DC, Xu R
CMS lists Wegovy as an eligible GLP-1 drug for the Bridge when used to reduce excess body weight and maintain weight reduction
From a mechanistic perspective, tirzepatide's dual agonism at GIP and GLP-1 receptors is made possible by specific amino acid substitutions and modifications that allow it to bind effectively to both receptor types
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