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Some herbs such as yerba mate, ginseng, curcumin, and berberine have been shown to improve metabolic health markers, enhance weight loss, and can help you feel full by boosting GLP-1 production (19), Malhotra says

Patients with favorable FTO variants often achieve strong weight loss even at lower doses, while those with less responsive variants may benefit from earlier dose escalation or dual-compound protocols like GLP-Squared

Protein & muscle preservation is projected to lead Nutrition Focus at 40.8% share in 2026

Tirzepatide: the dual GLP-1 + GIP agonist Tirzepatide is a 39-amino-acid synthetic peptide (molecular weight ~4,814 Da) engineered to bind both GLP-1R and GIPR (Coskun et al., 2018)

However, numerous gaps in our knowledge of CV outcomes in T2D remain, and we believe that RWE studies can have a role here, by complementing CVOTs with supporting evidence where data generation in a RCT would not be feasible

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