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On the other hand, it is interesting to outline how the G6PD deficiency (variant A-) is associated with an increase in the resistance to the infection caused by Plasmodium falciparum in the sub-Sahara region of Africa
When the availability of glycine is lower than necessary for sufficient glutathione synthesis, the initial molecule of cysteine and glutamate converts into a compound that is excreted
Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible
Nagasawa, Herbert T
doi: 10.3389/fmicb.2020.00090 74 HanLShuXWangJ
