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Some of the loss may actually be a good adaptation from a health perspective, he said

Based on this assumption, Ile 12 could be replaced with Leu or Val and retain the same effect

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However, because it does not block androgen or progesterone receptors like spironolactone, hormone-related adverse effects such as gynecomastia and menstrual irregularities are expected to occur less frequently

Xiao Liu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers