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It is possible that the effects are additive, that they are redundant, or that combining approaches produces unexpected outcomes

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In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18

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Theor Biol Med Mod