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Landmark trials include STEP (semaglutide for weight management, NEJM 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

Saliva: Morphine can be detected in saliva for up to 1-4 days after the last use, depending on the sensitivity of the testing method

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Spending on GLP-1 drugs for currently covered uses under Medicare and Medicaid has increased substantially in a relatively short period of time and could increase further with expanded coverage of GLP-1s for obesity, even at the lower net prices for these medications under both demonstrations

Identify foods that trigger discomfort: Pay attention to how different foods make you feel

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