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However, no reduction in dose is required for any of the GLP-1 RAs marketed today according to kidney function
The generalized deletion of the PGRN-encoded Grn gene improves insulin resistance and glucose intolerance in obese mice fed a high-fat diet (HFD)
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This last point is particularly relevant: type 2 diabetes has long been recognised as both a risk factor for and potential early manifestation of pancreatic cancer, creating a complex epidemiological relationship
Nauck MA, Quast DR, Wefers J, Meier JJ (2021) GLP-1 receptor agonists in the treatment of type 2 diabetes state-of-the-art
This information may help provide context for provider conversations about GLP-1 suitability and dose optimization, though genetic predisposition does not predict exact medication response
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