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Although it has not yet been reported, it is reasonable to expect that this defective GLP-1 secretion could be even more marked in women with PCOS and obesity

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For these reasons, uncertainty exists in the overall balance between benefits and risks/ burdens and surgical treatments are options

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Acknowledgements The authors from Pacific Northwest National Laboratory (PNNL) gratefully acknowledge the US Department of Energy (DOE), Energy Efficiency and Renewable Energy, Vehicle Technologies Office for the support of this work