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Tirzepatide has been shown to be as potent or more potent than GLP-1 RAs in patients with or without diabetes
They increase anti-inflammatory IL-10 levels in the heart 9
Given the natural fluctuations in hormone levels and the intricate rhythms of human physiology throughout the day and over a persons lifetime, there is concern about the uncertain health ramifications of sustained elevation of incretin activity over decades of treatment
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Your bodys ancient instincts kick in, quite literally seeing your calorie deficit as a threat to survival
The clinical value of patients being on a drug briefly is small, and serial increases and decreases in weight could be associated with lean muscle mass loss
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