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Particularly concerning, it appears that some studies were either canceled or stopped without conclusions

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Nov 2023;21(11):1172-1180 e1173

Antimicrobial sulfonamide metabolites are most likely responsible for nonIgE-mediated reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis

Nicotinamide riboside neutralizes hypothalamic inflammation and increases weight loss without altering muscle mass in obese rats under calorie restriction: a preliminary investigation

Regulatory and safety status: It's pending FDA review and not currently approved for use in humans