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Sometimes termed Phase III reactions, these usually consist of the removal of glutamyl and glycinyl groups and acetylation of cysteine to produce mercapturic acid or an N-acetylcysteine conjugate which can then be excreted, usually via bile or urine (Figure 2)

Preclinical and limited human studies indicate DSIP may modulate the hypothalamicpituitaryadrenal (HPA) axis and support healthy cortisol rhythms, making it of interest in stress-related sleep disruption

Ispoglou T, White H, Preston T, McElhone S, McKenna J, Hind K

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