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Eggers and Beggs tests were applied to assess funnel plot symmetry quantitatively.29 We also used the CINeMA (Confidence in Network Meta-Analysis) framework to assess the certainty of the evidence in six key areas, including within-study bias, reporting bias, indirectness, imprecision, heterogeneity, and inconsistency.3031 We assessed intransitivity for the CINeMA framework by comparing potential effect modifiers, such as baseline age and HbA 1c concentration, between studies that provided direct and indirect evidence for each comparison

Maintaining adequate hydration and gradually increasing fibre intake can help manage these symptoms